Hepatocellular carcinoma (HCC) and Lung cancer are the leading 2 cancer deaths in Taiwan. Thus, these 2 cancers are the most important cancers in Taiwan, and both have been chosen as the main target diseases by National Research Program. For HCC and lung cancer, only the early stage patients (<20%) who could receive surgical resection can have long survivals. There is still no good drug for long survival. The recent advances in genomics and proteomics led to discoveries of numerous promising new biomarkers in cancer research. The availability of large number, high quality cancer tissues to validate those biomarkers has become a major bottleneck for cancer researchers in Taiwan. To solve this bottleneck, NRPGM has established a liver cancer research network in 2005 (Taiwan Liver Cancer Network, TLCN), which coordinated 5 major medical centers in northern, central, and southern parts of Taiwan (NTUH, CGMH-Linko, Taichung VGH, CGMH-Kaohsiung, Kaohsiung VGH) to recruit liver cancer patients with regional representativeness. All participating centers followed a common protocol to collect liver cancer specimens as well as the patients’ clinical, pathological and epidemiological information. All samples and data are saved in the National Health Research Institutes Biobank with good management. TLCN has successfully recruited 7,838 patients, received 110 applications and sent out 43,240 biospecimens to the applicants by the end of 2015. In addition, NHRI Biobank also became in charge of all of the biosamples from the previous “Taiwan lung cancer tissue/specimen and information resource center” (SB4) project in August, 2015. SB4 project had great difficulties in getting fresh frozen lung cancer tissue. Even though SB4 has collected 639 lung cancer patients’ blood samples, but it only included 49 patients’ fresh frozen tumor tissue samples. We need to collect more lung cancer tissues of better quality to make it become an attractive tissue bank for lung cancer researchers. Thus, we would like to propose and organize a lung cancer research network in the same style as TLCN, that also coordinate 5 major medical centers in northern, central, and southern parts of Taiwan (NTUH, CGMH-Linko, Chung-Shan Medical University Hospital, CGMH-Kaohsiung, Kaohsiung VGH), so that we will also be able to collect lung cancer tissue samples with good quality and regional representativeness. The final goal is to improve the treatment and survival of liver cancer and lung cancer patients in Taiwan.