Publication

  1. Ya-Wen Lin, Ming-De Yan, Yu-Lueng Shih, Chung-Bao Hsieh. The basal body gene, RPGRIP1L, is a candidate tumour suppressor gene in human hepatocellular carcinoma. European J Cancer 2009: 2041-2049. 4.819
  2. Hsieh SY, Huang SF, Yu MC, Yeh TS, Chen TC, Lin YJ, Chang CJ, Sung CM, Lee YL, Hsu CY. Stathmin1 overexpression associated with polyploidy, tumor-cell invasion, early recurrence, and poor prognosis in human hepatoma. Mol Carcinog. 2010 May;49(5):476-87. 4.770
  3. Liang TJ, Mok KT, Liu SI, Huang SF, Chou NH, Tsai CC, Chen IS, Yeh MH, Chen YC, Wang BW. Hepatitis B genotype C correlated with poor surgical outcomes for hepatocellular carcinoma. J Am Coll Surg. 2010 Nov;211(5):580-6. Epub 2010 Sep 20. 4.454
  4. Hsieh SY, He JR, Hsu CY, Chen WJ, Bera R, Lin KY, Shih TC, Yu MC, Lin YJ, Chang CJ, Weng WH, Huang SF. Neuregulin/erythroblastic leukemia viral oncogene homolog 3 autocrine loop contributes to invasion and early recurrence of human hepatoma. Hepatology. 2011 Feb;53(2):504-16 11.190
  5. Tao Y, Ruan J, Yeh SH, et al. Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data.Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12042-7. Epub 2011 Jul 5. 9.809
  6. Chen MH, Yang WL, Lin KT, Liu CH, Liu YW, Huang KW, Chang PM, Lai JM, Hsu CN, Chao KM, Kao CY, Huang CY. Gene expression-based chemical genomics identifies potential therapeutic drugs in hepatocellular carcinoma. PLoS One. 2011;6(11):e27186. doi: 10.1371/journal.pone.0027186. Epub 2011 Nov 7. 3.534
  7. Chen JS, Su IJ, Leu YW, Young KC, Sun HS. Expression of T-cell lymphoma invasion and metastasis 2 (TIAM2) promotes proliferation and invasion of liver cancer. Int J Cancer. 2012;130:1302-1313. 5.007
  8. Yen, Chia-Hung, Lu, Yao-Cheng, Li, Chung-Hsien, Lee, Cheng-Ming, Chen, Chia-Yen, Cheng, Ming-Yuan, Shiu-Feng Huang, Chen, Kuen-Feng, Cheng, Ann-Lii, Liao, Li-Ying, Wu-Lee, Yan-Hwa, Chen, Yi-Ming. Functional characterization of Glycine N-methyltransferase and its interactive protein-DEPDC6/DEPTOR in hepatocellular carcinoma. Molecular Medicine 2012 Mar 30;18(3):286-96. 4.824
  9. Yi-Jen Liao, Tzu-Lang Chen, Tzong-Shyuan Lee, Hsiang-An Wang, Chung-Kwe Wang, Li-Ying Liao, Ren-Shyan Liu, Shiu-Feng Huang, and Yi-Ming Arthur Chen. Glycine N-methyltransferase Deficiency Affects Niemann-Pick Type C2 Protein Stability and Regulates Hepatic Cholesterol Homeostasis. Molecular Medicine 2012 May 9;18(1):412-22, Epub 2011, Dec. 4.824
  10. Lu JW, Hsia Y, Yang WY, Lin YI, Li CC, Tsai TF, Chang KW, Shieh GS, Tsai SF, Wang HD, Yuh CH. Identification of the common regulators for hepatocellular carcinoma induced by hepatitis B virus X antigen in a mouse model. Carcinogenesis. 2012 Jan;33(1):209-19. doi: 10.1093/carcin/bgr224. Epub 2011 Oct 21. 5.266
  11. Tzu-Ching Kuo, Ph.D.; Pu-Yuan Chang, Ph.D.; Shiu-Feng Huang, MD, Ph.D.; Chen-Kung Chou, Ph.D.; Chuck C.-K. Chao, Ph.D. Knockdown of HURP inhibits the proliferation of hepacellular carcinoma cells via downregulation of gankyrin and accumulation of p53. Biochemical Pharmacology 2012;83:758-768. 4.650
  12. Tsao CM, Yan MD, Shih YL, Yu PN, Kuo CC, Lin WC, Li HJ, Lin YW. SOX1 functions as a tumor suppressor by antagonizing the WNT/β-catenin signaling pathway in hepatocellular carcinoma. Hepatology. 2012 Dec;56(6):2277-87. doi: 10.1002/hep.25933. 11.190
  13. Wang SH, Yeh SH, Lin WH, Yeh KH, Yuan Q, Xia NS, Chen DS, Chen PJ. Estrogen receptor α represses transcription of HBV genes via interaction with hepatocyte nuclear factor 4α. Gastroenterology. 2012 Apr;142(4):989-998.e4. Epub 2012 Jan 10. 13.926
  14. Lin ZS, Chu HC, Yen YC, Lewis BC, Chen YW. Krüppel-like factor 4, a tumor suppressor in hepatocellular carcinoma cells reverts epithelial mesenchymal transition by suppressing slug expression. PLoS One. 2012;7(8):e43593. doi: 10.1371/journal.pone.0043593. Epub 2012 Aug 24. 3.534
  15. Chen PJ, Yeh SH, Liu WH, Lin CC, Huang HC, Chen CL, Chen DS, Chen PJ. Androgen pathway stimulates microRNA-216a transcription to suppress the tumor suppressor in lung cancer-1 gene in early hepatocarcinogenesis. Hepatology. 2012 Aug;56(2):632-43. doi: 10.1002/hep.25695. Epub 2012 Jun 11. 11.190
  16. Shih YL, Hsieh CB, Yan MD, Tsao CM, Hsieh TY, Liu CH, Lin YW. Frequent concomitant epigenetic silencing of SOX1 and secreted frizzled-related proteins (SFRPs) in human hepatocellular carcinoma. J Gastroenterol Hepatol. 2013 Mar;28(3):551-9 3.627
  17. Lo SJ, Fan LC, Tsai YF, Lin KY, Huang HL, Wang TH, Liu H, Chen TC, Huang SF, Chang CJ, Lin YJ, Yung BY, Hsieh SY. A novel interaction of nucleophosmin with BCL2-associated X protein regulating death evasion and drug sensitivity in human hepatoma cells.Hepatology. 2013 May;57(5):1893-905. doi: 10.1002/hep.26209. Epub 2013 Apr 1. 11.190
  18. Huang YH, Lin YH, Chi HC, Liao CH, Liao CJ, Wu SM, Chen CY, Tseng YH, Tsai CY, Lin SY, Hung YT, Wang CJ, Lin CD, Lin KH. Thyroid Hormone Regulation of miR-21 Enhances Migration and Invasion of Hepatoma. Cancer Res. 2013 Apr 15;73(8):2505-17. doi: 10.1158/0008-5472.CAN-12-2218. Epub 2013 Feb 26. 9.284
  19. Charles Balabaud, Wesal R. Al-Rabih, Pei-Jer Chen, Kimberley Evason, Linda Ferrell, Juan C. Hernandez-Prera, Shiu-Feng Huang, Thomas Longerich, Young Nyun Park, Alberto Quaglia, Peter Schirmacher, Christine Sempoux, Swan N. Thung, Michael Torbenson, Aileen Wee, Matthew M. Yeh, Shiou-Hwei Yeh, Brigitte Le Bail, Jessica Zucman-Rossi, and Paulette Bioulac-Sage. Focal Nodular Hyperplasia and Hepatocellular Adenoma around the World Viewed through the Scope of the Immunopathological Classification. Int J Hepatol vol. 2013, Article ID 268625, 12 pages, 2013. 非SCI
  20. Lin IY, Yen CH, Liao YJ, Lin SE, Ma HP, Chan YJ, Chen YM. Identification of FKBP11 as a biomarker for hepatocellular carcinoma.Anticancer Res. 2013 Jun;33(6):2763-9. 1.872
  21. Chen MH, Jan YH, Chang PM, Chuang YJ, Yeh YC, Lei HJ, Hsiao M, Huang SF, Huang CY, Chau GY. Expression of GOLM1 Correlates with Prognosis in Human Hepatocellular Carcinoma. Ann Surg Oncol. 2013;20 Suppl 3:S616-24. 3.943
  22. Yang-Hsiang Lin, Chia-Jung Liao, Ya-Hui Huang, Meng-Han Wu, Hsiang-Cheng Chi, Sheng-Ming Wu, Cheng-Yi Chen, Yi-Hsin Tseng, Chung-Ying Tsai, I-Hsiao Chung, Tzu-I, Wu, Ming-Ming Tsai, Crystal D. Lin, and K-H Lin (corresponding author) Thyroid hormone receptor represses miR-17 expression to enhance tumor metastasis in human hepatoma cells. Oncogene 2013; 32 (38), 4509-4518. 8.559
  23. Chen JS, Hung WS, Chan HH, Tsai SJ, Sun HS. In silico identification of oncogenic potential of fyn-related kinase in hepatocellular carcinoma. Bioinformatics. 2013 Feb 15;29(4):420-7. 4.621
  24. Shih TC, Tien YJ, Wen CJ, Yeh TS, Yu MC, Huang CH, Lee YS, Yen TC, Hsieh SY. MicroRNA-214 downregulation contributes to tumor angiogenesis by inducing secretion of the hepatoma-derived growth factor in human hepatoma. J Hepatol. 2012 Sep;57(3):584-91. 10.401
  25. Liao YJ, Lin MW, Yen CH, Lin YT, Wang CK, Huang SF, Chen KH, Yang CP, Chen TL, Hou MF, Arthur Chen YM. Characterization of Niemann-Pick Type C2 protein expression in multiple cancers using a novel NPC2 monoclonal antibody.PLoS One. 2013 Oct 17;8(10):e77586. doi: 10.1371/journal.pone.0077586. eCollection 2013. 3.234 (2014 JCR Science Edition)
  26. Hsei-Wei Wang, Tsung-Han Hsieh, SSu-Yi Huang, Gar-Yang Chau, Chien-Yi Tung, Chien-Wei Su and Jaw-Ching Wu. Forfeited hepatogenesis program and increased embryonic stem cell traits in young hepatocellular carcinoma (HCC) comparing to elderly HCC. BMC Genomics 2013, 14:736 4.041
  27. Liu WH, Chen CH, Yeh KH, Li CL, Wu YJ, Chen DS, Chen PJ, Yeh SH. ADAR2-Mediated Editing of miR-214 and miR-122 Precursor and Antisense RNA Transcripts in Liver Cancers. PLoS One. 2013 Dec 27;8(12):e81922. 3.534
  28. Lin KT, Shann YJ, Chau GY, Hsu CN, Huang CY. Identification of latent biomarkers in hepatocellular carcinoma by ultra-deep whole-transcriptome sequencing. Oncogene. 2014;33(39):4786-94.doi: 10.1038/onc.2013.424. [Epub ahead of print] 8.559
  29. Lee MH, Yang HI, Lu SN, Jen CL, You SL, Wang LY, L’italien G, Chen CJ, Yuan Y; for the REVEAL-HCV Study Group. Hepatitis C Virus Genotype 1b Increases Cumulative Lifetime Risk of Hepatocellular Carcinoma. Int J Cancer. 2014;135(5):1119-26 doi: 10.1002/ijc.28753. [Epub ahead of print] 5.007
  30. Lan SH, Wu SY, Zuchini R, Lin XZ, Su IJ, Tsai TF, Lin YJ, Wu CT, Liu HS. Autophagy suppresses tumorigenesis of hepatitis B virus-associated hepatocellular carcinoma through degradation of miR-224. Hepatology.2014 Feb;59(2):505-17. 11.190
  31. Ya-Wen Lin, Yu-Lueng Shih, Gi-Shih Lien, Fat-Moon Suk, Chung-Bao Hsieh, and Ming-De Yan. Promoter Methylation of SFRP3 Is Frequent in Hepatocellular Carcinoma. Disease Markers, Volume 2014, Article ID 351863, 10 pages (in press) 2.174
  32. Bera R, Chiou CY, Yu MC, Peng JM, He CR, Hsu CY, Huang HL, Ho UY, Lin SM, Lin YJ, Hsieh SY. Functional genomics identified a novel protein tyrosine phosphatase receptor type F-mediated growth inhibition in hepatocarcinogenesis. Hepatology. 2014 Jun;59(6):2238-50. doi: 10.1002/hep.27030. [Epub ahead of print] 11.190
  33. Chang SW, Fann CS, Su WH, Wang YC, Weng CC, Yu CJ, Hsu CL, Hsieh AR, Chien RN, Chu CM, Tai DI. A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese. PLoS One. 2014 Jun 18;9(6):e99724. doi: 10.1371/journal.pone.0099724. eCollection 2014. 3.534
  34. Su JC, Tseng PH, Wu SH, Hsu CY, Tai WT, Li YS, Chen IT, Liu CY, Chen KF, Shiau CW. SC-2001 overcomes STAT3-mediated sorafenib resistance through RFX-1/SHP-1 activation in hepatocellular carcinoma. Neoplasia. 2014 Jul;16(7):595-605. doi: 10.1016/j.neo.2014.06.005. Epub 2014 Jul 18. 5.398
  35. Kuo CC, Lin CY, Shih YL, Hsieh CB, Lin PY, Guan SB, Hsieh MS, Lai HC, Chen CJ, Lin YW. Frequent methylation of HOXA9 gene in tumor tissues and plasma samples from human hepatocellular carcinomas. Clin Chem Lab Med. 2014 Aug 1;52(8):1235-45 2.955
  36. Li CL, Yeh KH, Liu WH, Chen CL, Chen DS, Chen PJ, Yeh SH. Elevated p53 promotes the processing of miR-18a to decrease estrogen receptor-α in female hepatocellular carcinoma. Int J Cancer. 2015 Feb 15;136(4):761-70. 5.007
  37. Yang-Hsiang Lin, Meng-Han Wu, Chia-Jung Liao, Ya-Hui Huang, Hsiang-Cheng Chi, Sheng-Ming Wu, Cheng-Yi Chen, Yi-Hsin Tseng, Chung-Ying Tsai, I-Hsiao Chung, Ming-Ming Tsai, Ching-Ying Chen, Tina P. Lin, Yung-Hsin Yeh,Wei-Jan Chen and K-H Lin. Repression of microRNA-130b by thyroid hormone enhances cell motility. J Hepatology. 2015 June;62(6):1328-1340. 10.401
  38. Chia-Jung Liao, Hsiang-Cheng Chi, Chung-Ying Tsai, Chi-De Chen, Sheng-Ming Wu, Yi-Hsin Tseng, Yang-Hsiang Lin, I-Hsiao Chung, Ching-Ying Chen, Syuan-Ling Lin, Shiu-Feng Huang, Ya-Hui Huang, and K-H Lin. A novel small-form NEDD4 regulates cell invasiveness and apoptosis to promote tumor metastasis. Oncotarget 2015 Apr 20;6(11):9341-54. 6.627
  39. Kuo CC, Shih YL, Su HY, Yan MD, Hsieh CB, Liu CY, Huang WT, Yu MH, Lin YW. Methylation of IRAK3 is a novel prognostic marker in hepatocellular carcinoma. World J Gastroenterol. 2015 Apr 7;21(13):3960-9. doi: 10.3748/wjg.v21.i13.3960. 2.433
  40. Chung IH, Chen CY, Lin YH, Chi HC, Huang YH, Tai PJ, Liao CJ, Tsai CY, Lin SL, Wu MH, Chen CY, Lin KH. Thyroid hormone-mediated regulation of lipocalin 2 through the Met/FAK pathway in liver cancer. Oncotarget. 2015 Jun 20;6(17):15050-15064. 6.627
  41. Shih YT, Wang MC, Zhou J, Peng HH, Lee DY, Chiu JJ. Endothelial progenitors promote hepatocarcinoma intrahepatic metastasis through monocyte chemotactic protein-1 induction of microRNA-21. Gut2015 Jul;64(7):1132-1147. 13.319
  42. Ciou SC, Chou YT, Liu YL, Nieh YC, Lu JW, Huang SF, Chou YT, Cheng LH, Lo JF, Chen MJ, Yang MC, Yuh CH, Wang HD. Ribose-5-phosphate isomerase A regulates hepatocarcinogenesis via PP2A and ERK signaling. Int J Cancer. 2015 Jul 1;137(1):104-15. doi: 10.1002/ijc.29361. Epub 2014 Dec 12. 5.007
  43. Ou DL, Shyue SK, Lin LI, Feng ZR,Liou JY, Fan HH, Lee BS, Hsu C, Cheng AL. Growth arrest DNA damage-inducible gene 45 gamma expression as a prognostic and predictive biomarker in hepatocellular carcinoma. Oncotarget. 2015 Jun 29. [Epub ahead of print] 6.359 (2014 JCR Science Edition)
  44. Liao YJ, Fang CC, Yen CH, Hsu SM, Wang CK, Huang SF, Liang YC, Lin YY, Chu YT, Arthur Chen YM. Niemann-Pick type C2 protein regulates liver cancer progression via modulating ERK1/2 pathway: Clinicopathological correlations and therapeutical implications.Int J Cancer. 2015 Sep;137(6):1341-51. doi: 10.1002/ijc.29507. Epub 2015 Mar 24. 5.085 (2014 JCR Science Edition)
  45. Mei-Hsuan Lee, Hwai-I Yang, Sheng-Nan Lu, Yu-Ju Lin, Chin-Lan Jen, Kang-Hsuan Wong, Soa-Yu Chan, Liang-Chun Chen, Li-Yu Wang, Gilbert L’Italien, Yong Yuan & Chien-Jen Chen. Polymorphisms near the IFNL3 Gene Associated with HCV RNA Spontaneous Clearance and Hepatocellular Carcinoma Risk. Sci Rep. 2015 Nov 25;5:17030. doi: 10.1038/srep17030. 5.578
  46. Wen-Shu Chen, Chia-Jui Yen, Yun-Ju Chen, Jhen-Yu Chen, Li-Yun Wang, Shu-Jun Chiu, Wen-Ling Shih, Chien-Yi Ho, Tzu-Tang Wei, Hsiao-Lin Pan, Pei-Hsuan Chien, Mien-Chie Hung, Ching-Chow Chen, Wei-Chien Huang. miRNA-7/21/107 contribute to HBx-induced hepatocellular carcinoma progression through suppression of maspin.Oncotarget. 2015 Sep 22;6(28):25962-74. doi: 10.18632/oncotarget.4504. 6.359
  47. Hu HH, Liu J, Lin YL, Luo WS, Chu YJ, Chang CL, Jen CL, Lee MH, Lu SN, Wang LY, You SL, Yang HI, Chen CJ; REVEAL-HBV Study Group. The rs2296651 (S267F) variant on NTCP (SLC10A1) is inversely associated with chronic hepatitis B and progression to cirrhosis and hepatocellular carcinoma in patients with chronic hepatitis B. Gut. 2015 Dec 7. pii: gutjnl-2015-310686. doi: 10.1136/gutjnl-2015-310686. [Epub ahead of print]  14.921
  48. Shiu-Feng Huang, Hong-Dar Isaac Wu, Ya-Ting Chen, Saravana R. K. Murthy, Yu-Ting Chiu, Yu-Chang, Il-Chi Chang, Xuyu Yang, and Y. Peng Loh. Carboxypeptidase E is a prediction marker for tumor recurrence in the early stage hepatocellular carcinoma. Tumor Biology 2016, Jan. 23, published online. Doi: 10.1007/s13277-016-4814-7. 3.611
  49. Il-Chi Chang, PhD., Shiu-Feng Huang, MD.,PhD.,(corresponding author) Pei-Jer Chen, MD.,PhD., Chi-Ling Chen, PhD.,4Chao-Long Chen, MD., Cheng-Chung Wu, MD., Cheng-Chung Tsai, MD., Po-Huang Lee, MD., Miin-Fu Chen, MD.,Chuan-Mo Lee, MD., Hsien-Chung Yu, MD., Gin-Ho Lo, MD., Chau-Ting Yeh, MD.,PhD., Chih-Chen Hong, PhD., Hock-Liew Eng, MD., John Wang, MD., Hui-Hwa Tseng, MD., Cheng-Hsiang Hsiao, MD., Hong-Dar Isaac Wu, PhD., Tseng-Chang Yen, PhD., Yun-Fan Liaw MD. The hepatitis viral status in patients with hepatocellular carcinoma – a study of 3843 patients from Taiwan Liver Cancer Network. Medicine 2016 Apr;95(15):e3284. 5.723 (ranking: 9.7%)
  50. Yu-Lueng Shih, Chih-Chi Kuo, Ming-De Yan, Ya-Wen Lin, Chung-Bao Hsieh, and Tsai-Yuan Hsieh. Quantitative methylation analysis reveals distinct association between PAX6 methylation and clinical characteristics with different viral infections in hepatocellular carcinoma. Clin Epigenetics. 2016 Apr 22;8:41. doi: 10.1186/s13148-016-0208-3. eCollection 2016.4.543
  51. Liu J, Yang HI, Lee MH, Jen CL, Hu HH, Lu SN, Wang LY, You SL, Huang YT, Chen CJ. Alcohol Drinking Mediates the Association between Polymorphisms of ADH1B and ALDH2 and Hepatitis B-Related Hepatocellular Carcinoma. Cancer Epidemiol Biomarkers Prev. 2016 Apr;25(4):693-9. doi: 10.1158/1055-9965.EPI-15-0961. Epub 2016 Jan 31.3.622
  52. Lin YF, Li LH, Lin CH, Tsou MH, Chuang MT, Wu KM, Liao TL, Li JC, Wang WJ, Tomita A, Tomita B, Huang SF, Tsai SF. Selective Retention of an Inactive Allele of the DKK2 Tumor Suppressor Gene in Hepatocellular Carcinoma. PLoS Genet. 2016 May 20;12(5):e1006051. doi: 10.1371/journal.pgen.1006051. eCollection 2016. 6.1
  53. Hao-Kang Li, Ru-Tsun Mai, Hsien-Da Huang, Chih-Hung Chou, Yi-An Chang, Yao-Wen Chang, Li-Ru You, Chun-Ming Chen, and Yan-Hwa Wu Lee. DDX3 Represses Stemness by Epigenetically Modulating Tumor-suppressive miRNAs in Hepatocellular Carcinoma. Sci Rep. 2016 Jun 27;6:28637. doi: 10.1038/srep28637.5.578
  54. Wen-Shu Chen, Liang-Chih Liu, Chia-Jui Yen, Yun-Ju Chen, Jhen-Yu Chen, Chien-Yi Ho, Shu-Hui Liu, Ching-Chow Chen, Wei-Chien Huang. Nuclear IKKα mediates microRNA-7/-103/107/21 inductions to downregulate maspin expression in response to HBx overexpression. Oncotarget. 2016 Jul 7. doi: 10.18632/oncotarget.10462. [Epub ahead of print]6.359
  55. Hsiang-Cheng Chi, Shen-Liang Chen, Chung-Ying Tsai, Wen-Yu Chuang, Ya-Hui Huang, Ming-Ming Tsai,f Sheng-Ming Wu, Cheng-Pu Sun, Chau-Ting Yeh, and Kwang-Huei Lin. Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy. Autophagy. 2016 DEC; 12(12): 2271–2285. 8.593
  56. Yi-Hsin Tseng, Ya-Hui Huang, Tzu-Kang Lin, Sheng-Ming Wu, Hsiang-Cheng Chi, Chung-Ying Tsai, Ming-Ming Tsai, Yang-Hsiang Lin, Wei-Chun Chang, Ya-Ting Chang, Wei-Jan Chen, and Kwang-Huei Lin. Thyroid hormone suppresses expression of stathmin and associated tumor growth in hepatocellular carcinoma. Sci Rep. 2016 Dec 9;6:38756. doi: 10.1038/srep38756. 5.228
  57. Kuo TC, Chen CK, Hua KT, Yu P, Lee WJ, Chen MW, Jeng YM, Chien MH, Kuo KT, Hsiao M, Kuo ML. Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells. Cancer Lett. 2016 Dec 28;383(2):282-294. doi: 10.1016/j.canlet.2016.10.012. Epub 2016 Oct 8.5.992
  58. Wu SM, Lin SL, Lee KY, Chuang HC, Feng PH, Cheng WL, Liao CJ, Chi HC, Lin YH, Tsai CY, Chen WJ, Yeh CT, Lin KH. Hepatoma cell functions modulated by NEK2 are associated with liver cancer progression. Int J Cancer. 2017 Apr 1;140(7):1581-1596. doi: 10.1002/ijc.30559. Epub 2017 Jan 19. 7.36
  59. Li CH, Yen CH, Chen YF, Lee KJ, Fang CC, Zhang X, Lai CC1, Huang SF, Lin HK, Arthur Chen YM. Characterization of the GNMT-HectH9-PREX2 tripartite relationship in the pathogenesis of hepatocellular carcinoma. Int J Cancer. 2017 May 15;140(10):2284-2297. doi: 10.1002/ijc.30652. 7.36
  60. Yen CH, Lai CC, Liao CC, Wang SF, Liao YJ, Tung CY, Hung JH, Huang SF, Chen YA. Characterization of a new murine cell line of sarcomatoid hepatocellular carcinoma and its application for biomarker/therapy development. Sci Rep. 2017 Jun 8;7(1):3052. doi: 10.1038/s41598-017-03164-3.4.259
  61. Hua KT, Liu YF, Hsu CL, Cheng TY, Yang CY, Chang JS, Lee WJ, Hsiao M, Juan HF, Chien MH, Yang SF. 3’UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma. Sci Rep. 2017 Jun 30;7(1):4466. doi: 10.1038/s41598-017-04732-3. 4.259
  62. Wu MS, Wang CH, Tseng FC, Yang HJ, Lo YC, Kuo YP, Tsai DJ, Tsai WT, Yu GY. Interleukin-17F expression is elevated in hepatitis C patients with fibrosis and hepatocellular carcinoma. Infect Agent Cancer. 2017 Jul 26;12:42. doi: 10.1186/s13027-017-0152-7. eCollection 2017. 2.123
  63. Kuo HH, Lin RJ, Hung JT, Hsieh CB, Hung TH, Lo FY, Ho MY, Yeh CT, Huang YL, Yu J, Yu AL. High expression FUT1 and B3GALT5 is an independent predictor of postoperative recurrence and survival in hepatocellular carcinoma. Sci Rep. 2017 Sep 7;7(1):10750. doi: 10.1038/s41598-017-11136-w. 4.259
  64. Yeh HW, Lee SS, Chang CY, Hu CM, Jou YS. Pyrimidine metabolic rate limiting enzymes in poorly-differentiated hepatocellular carcinoma are signature genes of cancer stemness and associated with poor prognosis. Oncotarget. 2017 Sep 8;8(44):77734-77751. doi: 10.18632/oncotarget.20774. eCollection 2017 Sep 29. 5.168
  65. Chi HC, Chen SL, Lin SL, Tsai CY, Chuang WY, Lin YH, Huang YH, Tsai MM, Yeh CT,  Lin KH. Thyroid hormone protects hepatocytes from HBx-induced carcinogenesis by  enhancing mitochondrial turnover. Oncogene. 2017 Sep 14;36(37):5274-5284. doi:  10.1038/onc.2017.136. Epub 2017 May 15. 6.854
  66. Lee MH, Huang YH, Chen HY, Khor CS, Chang YH, Lin YJ, Jen CL, Lu SN, Yang HI, Nishida N, Sugiyama M, Mizokami M, Yuan Y, L’Italien G, Tokunaga K, Chen CJ; REVEAL-HCV cohort. Human Leukocyte Antigen Variants and Risk of Hepatocellular Carcinoma Modified by HCV Genotypes: A Genome-wide Association Study. Hepatology. 2017 Sep 16. doi: 10.1002/hep.29531. [Epub ahead of print] 13.246
  67. Lin YY, Yu MW, Lin SM, Lee SD, Chen CL, Chen DS, Chen PJ. Genome-wide association analysis identifies a GLUL haplotype for familial hepatitis B virus-related hepatocellular carcinoma. Cancer. 2017 Oct 15;123(20):3966-3976. doi: 10.1002/cncr.30851. Epub 2017 Jun 29. 6.072
  68. Huang PS, Lin YH, Chi HC, Chen PY, Huang YH, Yeh CT, Wang CS, Lin KH. Thyroid hormone inhibits growth of hepatoma cells through induction of miR-214. Sci Rep. 2017 Nov 1;7(1):14868. doi: 10.1038/s41598-017-14864-1.4.259
  69. Lin SL, Wu SM, Chung IH, Lin YH, Chen CY, Chi HC, Lin TK, Yeh CT, Lin KH. Stimulation of Interferon-Stimulated Gene 20 by Thyroid Hormone Enhances Angiogenesis in Liver Cancer. Neoplasia. 2018 Jan;20(1):57-68. doi: 10.1016/j.neo.2017.10.007. Epub 2017 Nov 29.5.006
  70. Lin YH, Wu MH, Huang YH, Yeh CT, Cheng ML, Chi HC, Tsai CY, Chung IH, Chen CY, Lin KH. Taurine up-regulated gene 1 functions as a master regulator to coordinate glycolysis and metastasis in hepatocellular carcinoma. Hepatology. 2018 Jan;67(1):188-203. doi: 10.1002/hep.29462. Epub 2017 Nov 15.13.246
  71. Lin KT, Ma WK, Scharner J, Liu YR, Krainer AR. A human-specific switch of alternatively spliced AFMID isoforms contributes to TP53 mutations and tumor recurrence in hepatocellular carcinoma. Genome Res. 2018 Feb 15. doi: 10.1101/gr.227181.117. 11.922
  72. Lee MH*, Huang YH, Chen HY, Khor C SS, Chang YH, Lin YJ, Jen CL, Lu SN, Yang HI, Nishida N, Sugiyama M, Mizokami M, Yuan Y, L’Italien G, Tokunaga K, Chen CJ. Human leukocyte antigen variants and risk of hepatocellular carcinoma modified by HCV genotypes: a genome-wide association study. Hepatology, 2018; 67 (2): 651-661 (SCI, IF=14.1)
  73. Shiu-Feng Huang, Il-Chi Chang, Chih-Chen Hong, Tseng-Chang Yen, Chao-Long Chen, Cheng-Chung Wu, Cheng-Chung Tsai, Ming-Chih Ho, Wei-Chen Lee, Hsien-Chung Yu, Ying-Ying Shen, Hock-Liew Eng, John Wang, Hui-Hwa Tseng, Yung-Ming Jeng, Chau-Ting Yeh, Chi-Ling Chen, Pei-Jer Chen, Yun-Fan Liaw. Metabolic risk factors are associated with non-hepatitis B non-hepatitis C hepatocellular carcinoma in Taiwan, an endemic area of chronic hepatitis B. Hepatol Commun. 2018 Apr 18;2(6):747-759. doi: 10.1002/hep4.1182. eCollection 2018 Jun.
  74. Peng JM, Bera R, Chiou CY, Yu MC, Chen TC, Chen CW, Wang TR, Chiang WL, Chai SP, Wei Y, Wang H, Hung MC, Hsieh SY. Actin cytoskeleton remodeling drives epithelial-mesenchymal transition for hepatoma invasion and metastasis in mice. Hepatology. 2018 Jun;67(6):2226-2243. doi: 10.1002/hep.29678. Epub 2018 Apr 19. 14.079
  75. Wu SY, Lan SH, Wu SR, Chiu YC, Lin XZ, Su IJ, Tsai TF, Yen CJ, Lu TH, Liang FW, Li CY, Su HJ, Su CL, Liu HS. Hepatocellular carcinoma-related cyclin D1 is selectively regulated by autophagy degradation system. Hepatology. 2018 Jul;68(1):141-154. doi: 10.1002/hep.29781. Epub 2018 Mar 23. 14.079
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